GM PoopMates 😤. This is your Craptain speaking, bringing you another fresh edition of the PoopMates newsletter.

Today we’re going over a supplement that has been trending for quite some time now, and for good reason. Like many supplement trends over the years, there are many who swear by it and many calling it snake oil. So, who’s right?

🔵 Methylene Blue: Based or Blue Kool-Aid? 🔵

If you've spent even a minute in the health-obsessed corners of the internet lately, you've seen the blue-stained tongues of biohackers swearing by methylene blue. It’s the latest health craze tearing through social media, the Joe Rogan podcast, and every biohacker’s wet dream.

WTF is it?

Well, it’s got a long history. First off, it’s not a naturally occurring substance. It was first synthesized in 1876 as a textile dye but was soon discovered to have medicinal properties. It was also used as one of the first antibiotics, and even treated malaria in 1891. Today, it’s on the World Health Organization’s list of essential medicines, mainly for cyanide poisoning and a rare blood disorder called methemoglobinemia. It’s also commonly used as a fish tank cleaner lol.

But somewhere along the way, it got a rebrand. Now, it’s being touted as a next-level cognitive enhancer, mitochondrial booster, and even a cancer fighter. Every week a new post about it shows up on the feed and the debate over whether it actually works is getting heated.

Who’s Drinking the Blue Kool-Aid?

The methylene blue hype train is being driven by some big names:

✅ Robert F. Kennedy Jr. was spotted mixing something suspiciously blue into his water on an airplane. Cue the internet going wild.
✅ Bryan Johnson - Yup, the guy who spends $2 million per year on himself with the goal of living forever, takes it and posted about it here.
✅ Twitter health bros are all over it, treating it like it’s the IRL version of NZT from the movie Limitless. They’re even feeding to their pets.
✅ Joe Rogan guests like Chase Huges and Mel Gibson have brought it up multiple times, fueling curiosity even more.

The Supposed Benefits

The methylene blue believers claim it does a lot, and there are studies that back their claims:

⚡️ Boosts mitochondrial function – helps produce more ATP (cellular energy)
👴🏻 Acts as an antioxidant – potentially fights oxidative stress and slows aging
🧠 Enhances brain function – some studies suggest it might improve memory
🫁 Improves oxygen utilization – can help counteract hypoxia (low oxygen levels)
☢️ Fights cancer – ☢️ recent studies are exploring its role in photodynamic therapy to selectively kill cancer cells
💩 Gut protection – potentially aids gut health during traumatic injuries

Sounds great, right? Well, not everyone’s convinced.

The Anti-Methylene Blue Camp

Some experts are waving huge red flags about the trend:

❌ Andrew Huberman replied to Bryan Johnson mentioning it’s a no-go for many.
❌ Paul Saladino (Carnivore MD) thinks if you’re a healthy individual, it has nothing to offer, and may even be harmful. (His take)
❌ Many other doctors and researchers are concerned about serotonin syndrome and unknown long-term risks.

And they have every right to be concerned because there are some real risks to consider when taking MB.

The Potential Risks & Side Effects

🩶 Serotonin Syndrome – If you’re on SSRIs or other serotonergic drugs, methylene blue could be dangerous by spiking serotonin to toxic levels.
📏 Dosing is everything – Too much can cause dizziness and or nausea.
💊 It’s an MAO inhibitor – Meaning it interacts badly with certain medications and foods.
🧠 High doses stain your brain – Studies show it can literally turn your brain blue. — but, it’s rare and requires a massive dose.
🐁 Gut Health Impacts – A study on mice found that high doses of methylene blue led to significant changes in gut microbiota composition, increasing certain bacteria levels. However, lower doses didn't cause significant alterations.
🧪 Source matters – Methylene blue used for fish tank cleaners is NOT the same as the kind used in medicine. If you don’t want toxic heavy metals with your precious blue dye, make sure you’re sourcing your MB from a reputable dealer for minimal impurities.

So… Should You Try It?

First off, if you read our previous post on Red 3, I know what you’re thinking - “Didn’t you literally just write a post on why I should avoid color dyes? Now you’re telling me I should take this blue color dye?”

…No, that’s not what I’m saying.

You’re an adult. That means you should do your own research, weigh the risks, and make the decision yourself. I’m literally a piece of sh*t, what do I know? 💩

But if you’re curious, read up on it. There’s tons of literature on the subject that would make a newsletter post too boring for our average reader. If you end up taking it, your mitochondria might thank you, but your serotonin levels might might not. Only one way to find out!

The Verdict?

Methylene blue isn’t some brand-new health breakthrough—it’s a 150-year-old synthetic drug with real medical uses. It might have benefits in small, controlled doses, but chugging it because your favorite fit-fluencooors said so? Probably not the best move.

💩 SH*TTY MEMEZ 🤣

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That’s all for today, PoopMates. We hope you enjoyed it. Now go, fertilize the Earth! The planet needs you.

DISCLAIMER: The content provided in this newsletter is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. If you are experiencing a medical emergency, call your doctor or dial 911 immediately.