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For a while, nicotine was always associated with tobacco use. Times have changed and so have nicotine delivery methods. When toxic additives are removed, there is evidence that suggests nicotine may have positive impacts on gut health and more.
Let’s dive in.
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The Studies
There are countless studies on nicotine out there and I have zero desire to read though all of them. Here are some interesting ones that we’ll be reviewing that have gotten some attention regarding the positive impacts of nicotine use.
🔬 Research TL;DR
Nicotine’s effects on the gut are multifaceted. Here’s a quick rundown of what those studies claim to show:
Reduced Inflammation: Nicotine interacts with the cholinergic anti-inflammatory pathway, potentially reducing inflammation in conditions like ulcerative colitis. Some studies show nicotine can decrease inflammatory markers, such as TNF-α and IL-6, while increasing anti-inflammatory ones like IL-10.
Improved Gut Barrier Function: Research suggests nicotine could enhance tight junctions in gut cells, potentially improving the integrity of the gut lining. This effect could theoretically reduce “leaky gut” issues by strengthening the barrier that keeps out inflammatory triggers.
Enhanced Motility: Nicotine interacts with cholinergic receptors, which play a key role in stimulating gut motility. This stimulation can, in certain doses, promote digestion and alleviate constipation-like symptoms. (coffee + nicotine = iykyk 😏)
Symptoms in IBD Patients: In specific cases, like ulcerative colitis, some patients have seen improvement in stool frequency, abdominal pain, and fecal urgency with transdermal nicotine therapy. But these studies highlight a challenge: the high dose needed can cause side effects like nausea, limiting its practical use.
🚸 Research Conclusions
Ok so those studies had some interesting results. So what, if any, conclusions can be drawn from them?
Nicotine may reduces gut disorder risks. ⚠️
There’s a correlation between smoking and lower risk for ulcerative colitis, but the relationship is complex. Smoking increases the risk for Crohn’s disease and brings general health risks, so this point requires nuance.
Nicotine may improve ‘leaky gut’ by enhancing tight junction proteins. ⚠️
Some studies do show nicotine may affect gut lining proteins that maintain barrier integrity. However, more evidence is likely needed to confirm this effect in human patients with leaky gut.
Nicotine boosts gut motility. ✅
Nicotine acts on the cholinergic system, which indeed promotes motility. However, the effects vary by dose, and higher doses could potentially overstimulate and disrupt gut balance.
Nicotine activates the cholinergic anti-inflammatory pathway, reducing inflammation. ✅
Studies indicate nicotine’s interaction with cholinergic receptors can reduce inflammation. But chronic nicotine use can bring other health risks, so more targeted research is needed to harness these effects safely.
🚫 Our Takeaway
While nicotine may have some gut-related benefits, these effects are specific, complex, and not without risks, fam. Fr fr.
Pure nicotine may lack the harmful additives in cigarettes and vapes, but this is not an endorsement to start using nicotine for gut health.
I’m literally a piece of shit on the internet - what do I know?
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DISCLAIMER: The content provided in this newsletter is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. If you are experiencing a medical emergency, call your doctor or dial 911 immediately.